Chronic Fatigue Syndrome Practice Test 2026 - Free Practice Questions and Study Guide

Question: 1 / 400

What is a key indicator of Chronic Fatigue Syndrome?

Fatigue that improves with rest

Recurring headaches

Debilitating fatigue despite adequate rest

The key indicator of Chronic Fatigue Syndrome (CFS) is debilitating fatigue despite adequate rest. This symptom is often described as overwhelming and cannot be alleviated through rest or sleep, which distinguishes it from normal fatigue that might improve with rest. Individuals with CFS experience fatigue that significantly impairs their daily functioning and is often accompanied by other symptoms such as cognitive difficulties, sleep disturbances, and pain. The persistent nature of this fatigue, particularly its resistance to rest, is a hallmark feature that clinicians use to evaluate the condition.

In contrast to options discussing fatigue that improves with rest or symptoms like headaches and shortness of breath, the defining characteristic of CFS is the chronic and debilitating nature of the fatigue itself, making option C the most accurate representation of the disorder.

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Shortness of breath during exertion

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